Personal Competency Essay

Personal competencies represent a person’s ability, skill, character, and knowledge that develop through life experiences. Competencies are required to perform efficiently in any professional organization. The ability to fully understand his or her personal competencies and using it as a resourceful tool for improvement constructs the foundation of highly effective management department. Poor communication is often the biggest barrier in organizational effectiveness. In a managerial position, development of communication skills is an integral part for managers to build and maintain relationships by employee‘s self-concept. When expectations are known, uncertainties are reduced, outcomes can then be better predicted allowing the organization to run smoothly. To overcome conflicts and effectively communicate with different areas of the business, management uses communication technique to have a pleasant and productive work atmosphere. Clearly defining each position’s roles and responsibilities sets a foundation and reduces tension in the workplace. Employees feel valued when managers actively listen to concerns and allow workers to participate in any decision-making process. This helps build a positive, parallel relationship between the manager and employee. Keeping an open mind and knowing that disagreements can occur help contribute to advancement of a business by realizing that management may not always be right. Innovating and strategizing are the essential competencies to focus on in order to adapt strong communication skills. A successful innovative organization clearly explains to each employee the organization’s vision, mission, purpose and each position’s responsibilities. Making sure the vision is understood, trusting staff members and prioritizing meetings is a guiding light for an innovative organization. Strategizing also is another critical element that allows better communication. Reflecting on the previous year, and current year and planning for future years allows the organization to expand through the use of communication. Communication is the key to the success of many objectives and goals set by individuals and upper management. Recognizing each individual’s personality and finding various ways to communicate is an integral part of management in any organization.

(P2) in a Business Report: Task 2: Describe the Different Stakeholders Who Influence the Purpose of Two Business Organisations You Have Selected. Essay

In a business report: Task 2: Describe the different stakeholders who influence the purpose of two business organisations you have selected. NHS Stakeholder: Stakeholder is a person, group or organisation that has interest or concern in an organisation. Stakeholders can affect or be affected by the organisation’s actions, objectives and policies. Some examples of key stakeholders are creditors, directors, employees, government, owners (shareholders), suppliers, unions, and the community from which the business draws its resources. The stakeholders of NHS are: ïÆ'ËœManager – The manager influence NHS, because the manager is the one who makes decisions everyday which includes what medicine or service should be offered should be offered and the manager also decides who he/she should take into service or fire. ïÆ'ËœDoctor’s have influence on the patients as they have to help people by treating patient’s illness, providing advice and support, and seeing the effects of both ill health and good health from the patient’s point of view. They have to examine the symptoms presented by a patient, and consider a range of possible diagnoses. If they are unable to do this it will affect the patients and the company as the patients will lose their trust in the doctors, and as a result it will affect the company’s reputation. ïÆ'ËœPatient/Client have an influence on the company, because without the patients/clients NHS won’t have any service to offer. This means that if there are no patients then the Government will decide that the company should shut down. ïÆ'ËœAdmin and Clerical staff have a great influence on NHS, as they are responsible for paper work e.g. keeping patients records and send e-mails and letters to patients regarding their health. ASDA’s Stakeholder: The stakeholders of ASDA are: ïÆ'ËœEmployees influence ASDA because employees are the people who are responsible to carry out variety of business activities, e.g. they are involved in decision making of the business, controlling the Health and Safety regulations and planning the merchandise. ïÆ'ËœCustomers want low-priced, good products. Modern customers also have high expectations of organisations. They will want them to get involved in the local community. They will then want to know about them. ASDA stores and depots have community notice boards and a monthly magazine is produced which features community events. ïÆ'ËœSuppliers at a national level are the very large providers to ASDA. They will want to sell goods in volume at good prices. This gives them economies of scale. ASDA has worked hard at building up links with local suppliers. It works with small and medium-sized businesses that are able to provide products for groups of stores at terms that suit them. ïÆ'ËœColleagues like to serve the community. The retail industry is not highly paid – customers demand low prices and operations require a large number of colleagues. So working with the community helps to motivate colleagues. All the events that ASDA holds are shared in an in-house monthly newsletter.

Proposals Relation to the Education of Youth in Pennsylvania Essay

In the â€Å"Proposals Relation to the Education of Youth in Pennsylvania, Philadelphia,† 1749, Benjamin Franklin reconciled public service, the benefits of classical learning, and the necessity of practical training for young people in the colony. Mr. Franklin discussed that knowledge helps to give honor. Not just honor to yourself for knowing what you are doing and talking about but, also an honor for your country to represent them if you were to become a part of office and have to communicate with others outside of country. Not even just to be in office but, to also become a minister or priest for a religion thanks to the studies of religious and civil morality. Thanks to their knowledge the academy will give to them they will be able to help their country in not just honoring them but, helping the citizens in the country. Due to their knowledge they will be able to give the citizens fair amounts of income, fair prices for taxes, and prayers. The men that will have this knowledge will not only be from a rich background with an abundance of money and high class families. As well as, poor background young men with little money and probably no family at all have a chance to receive an education and help their country. Then after one school is built to help young men, more and more can be built by other men with knowledge and help others get the education they once received. In this academy the students will learn similar subjects to what the modern day student learns today. Students will be taught the English language by reading some of the best authors in the 1700’s. There was Tillotson, Pope, Cato’s Letters, and etc. hould be some of the classics read. They will be taught to write with neat handwriting, swift drawing of arithmetic, accounts†¦ geometry, and astronomy. All of these can count as basic classes to help with any future job the student might want to have/achieve when they graduate. These basic classes can also help with everyday jobs, for example, directions in the stars while on a journey in the ocean or lost in the fore st (science), buying or trading goods for money (math), or even just being able to read and write a form of a constitution or charter (grammar). Benjamin Franklin also states â€Å"But art is long, and their time is short. † in paragraph 8 of â€Å"Proposals Relation to the Education of Youth in Pennsylvania, Philadelphia,† 1749. In the passage, the author also talks of the necessities of practical training which has to do with knowing how to handle and work on machines and the histories on machine. Something that will be taught is the machines used in wars. Men can learn to make these machines and use them. Then they can improve them in ways to make them better so they can be used when needed. The knowledge of machines can help those week men that cannot do much physical work can invent new machines to reduce labor for all men and slaves. Manufacturing companies will begin to grow in ways of money and making more of what they sell. Their money will flourish and the companies will gain power. Once the companies grow, trade will also increase which can make that country gain more money also. That is when math and grammar also come in handy. Manufacturing companies will not only flourish but, farming as well because of the farming technique they give you, to plant cash crops and even plant your own foods to eat at home. Benjamin Franklin put to rights that public service, the benefits of classical learning, and the necessity of practical training for young men in the colonies by giving them knowledge to honor and help themselves and country. Next, the students learning the basics will help with future jobs and everyday lives. Lastly, the men learn to use and invent machines by learning their histories and how they were used. These arguments should make anyone want to open up an academy and teach young men.

Jalsberg Cheese Essay Example | Topics and Well Written Essays - 2500 words

Jalsberg Cheese - Essay Example The changing market environment has given rise to the needs of updated information more than ever in the past. The markets have transformed to international from local. With the increase in the exposure to masses and increased geographical market coverage, the need of quick and up to date information has also increased. With the changing business environment the buyers are also changing. With the increasing incomes the buyers have become more selective. For a company to launch its product in a new market it has become important to have the information from the buyer needs to buyer wants. On the other hand it is also important to have the knowledge of how to present the product in effective manner in order to reach the customer in an effective manner. With the changing business needs the new marketing techniques such as product differentiation, branding and advertising are also gaining immense importance. This paper is aimed at finding out the appropriate marketing communication strat egy for Jalsberg cheese which is a famous branded cheese in American Market and ready to be marketed in new European market. Norseland Inc. was founded in 1978. The purpose of the company was to market and distribute Jarlsberg and other Norwegian cheese in United States. The Company is a 100% owned subsidiary of TINE Norwegian Diaries, which has the main responsibility for the production and marketing of Jarlsberg cheese. Jalsberg cheese has some snob appeal. Customers want to show they have ‘good taste’. Without complaining they accept the higher price of Jalsberg compared to other competitive products. The mild and creamy taste appeals to Americans, and many think that the taste of the traditional Swiss cheese, Emmenthaie is too sharp Now the company is aiming to introduce its Cheese brand Jalsberg in the newly extended European market. In order to undertake successful brand positioning Norseland has to design a marketing communication strategy, which should be crafted according to the European market conditions and consumer behaviour.

The international criminal court Essay Example | Topics and Well Written Essays - 2500 words

The international criminal court - Essay Example The International Criminal Court was established to provide assistance in the most complex international crime situations. The ICC is a fully independent institution that operates in accordance with the Rome Statute and aims at dealing with the most serious international crimes, including crimes against humanity. Some of the most famous cases in the ICC included the case of Milosevich and prosecutions against the political and military leaders of Congo and Uganda. Based on the principles of legitimacy, fairness, and justice, the ICC exemplifies a successful attempt to resolve the most controversial crime situations and issues at the supranational level. The ICC: purpose and structure The International Criminal Court (ICC) is fairly regarded as the central and most important body in the criminal prosecution process. It â€Å"is the first permanent, treaty based, international criminal court established to help end impunity for the perpetrators of the most serious crimes of concern to the international community† (ICC 2010). Needless to say, the ICC is primarily concerned with the crimes against humanity and their consequences. It is a fully independent organization, which has nothing to do with any of the current international humanitarian unions and organizations, including the United Nations, and operates in accordance with â€Å"the norms and principles of the Rome Statute† (ICC 2010). ... the ICC, it is one of the most successful legal courts ever created by humanity – it helps to reach and further maintains â€Å"international consensus on the most problematic definitions of war crimes, genocides, and other crimes against humanity† (ICC 2010). There is an emerging consensus that impunity in the modern society contradicts the basic principles of humanitarian activity and is simply unacceptable (ICC 2010). Following the end of the civil conflicts in Yugoslavia and Rwanda, the International Criminal Tribunal tried but failed to achieve the purpose of global justice; and it was not before 1998 that a new international court was created to support the humanity in its movement toward stability and peace. The ICC is a complex institutional body, which comprises Presidency, Judicial divisions, Office of the Prosecutor, Registry, and other offices (ICC 2010). â€Å"Although the ICC has never been a part or member of the United Nations organization, it maintains productive cooperative ties with the UN† (ICC 2010). Three Judges make up the court’s Presidency, which is primarily responsible for managing, administering, and monitoring all Court’s operations, â€Å"with the exception of the Prosecutor† (ICC 2010). â€Å"The Presidency is elected by other, fellow judges, for a three years’ term† (ICC 2010). The ICC’s current President is Sang-Huyn Song, whereas Judges Fatoumata Dembele Diarra and Hans-Peter Kaul are the first and second vice-presidents, accordingly (ICC 2010). The Court consists of the Pre-Trial, Trial, and Appeals divisions, with eighteen judges in them (ICC 2010). Each division has six judges, which are responsible for proceedings at different stages of the criminal prosecution process (ICC 2010). In its turn, the Office of the Prosecutor’s

Article Critique Assignment Example | Topics and Well Written Essays - 750 words - 1

Article Critique - Assignment Example In Keohane’s article entitled â€Å"Imaginary fiends,† he states that there is a discrepancy between the actual decrease in crime rates and the beliefs of the American public regarding crime. Keohane presents arguments that show how the public is both mentally and emotionally made to believe that â€Å"crime got worse in the United States in 2009† (2009). In his article, he presents facts that show how â€Å"we’ve come to believe what we believe† and how the public needs to â€Å"take some steps toward mending our relationship with reality† (Keohane, 2009). Warr’s article entitled â€Å"Fear of Crime in the United States: Avenues for Research and Policy† takes a similar route of argument as Keohane’s. Warr argues that people should know accurate information about the status of crimes because while â€Å"Fear†¦under many circumstances†¦is beneficial†¦under the wrong circumstances, [it] can unnecessarily con strain behavior, restrict freedom and personal opportunity, and threaten the foundation of communities† (Warr, 2000, p.482). ... His article shows the extent of his research regarding the topic. Similarly, Warr’s article utilizes ethos. Firstly, Warr is a known criminologist who has authored several books and articles regarding crime. His background alone can be qualified as valid argument in terms of credibility. Furthermore, his article boasts of extensive research, just like Keohane’s. He presents both quantitative and qualitative analyses coming from various credible government and non-government sources. The only issue, however, could be that Warr’s sophisticated presentation may be a bit hard to follow at first especially for those who are not familiar with the sociology of crime. Keohane uses pathos, or the appeal to the emotions as well. At the onset of the article, he immediately grasps the audience’s attention by saying, â€Å"The year 2009 was a grim one for many Americans†¦Ã¢â‚¬  (Keohane, 2009). Immediately, he is able to communicate that his article is something that should interest his target audience --- the American public. He goes on to say that, â€Å"Citizens, though ground down and nerve-racked by the recession, still somehow resisted the urge to rob and kill one another†¦Ã¢â‚¬  (Keohane, 2009). This appeals to the emotions because Keohane establishes agreement with an underlying value common among the audience, and at the same time, he paints a positive scenario of the audience. Warr’s article, on the same note, utilizes pathos, but this time by discussing the nature of â€Å"fear.† Fear is a strong emotion and every reader would understand what Warr wants to say in terms of fear of crime. He appeals to his audience’s emotions by making this emotion of fear as one of the main foundations of his argument. Logos, or the

A Comparative Study of UK and Pakistan Research Paper

A Comparative Study of UK and Pakistan - Research Paper Example The study explores in great detail various design processes as influenced by globalization, which threaten to blur social, political and economic differences around the world. As such, this is a cross-disciplinary that explores global influences on the connections between culture and context design, media design and industrial designs in the development of textile products that not only meet but exceed global expectations. The paper also examines whether and how the superior design innovation curriculums such as the British may be introduced in Pakistan to bring the country’s technology resources, design ideas and principles up to speed with current and future global demands. The paper critically analyses three primary areas of textile design innovation, namely; culture and context design, industrial designs and media design. Firstly, culture and context design in both the United Kingdom and Pakistan will be analysed to establish the similarities between the two countries and what each country can learn from the other. As such, theories, notions and historical beliefs that influence design innovation within modern academies and studios will be explored in detail. Secondly, the study will explore industrial texture designs in general and how globalization continues to improve design innovation and the knowledge-base of both Pakistani and British. Greater focus will be placed on how the artists come up with textiles that meet the needs of the current and future worlds.

Managment Class and Self-Awareness for Team Membership Case Study

Managment Class and Self-Awareness for Team Membership - Case Study Example On the other Mia is willing to analyze other’s work and only bring out the change by taking corrective measures if necessary. 2. Carver is more inclined towards lower wanted to control (wC) and high expressed control score in FIRO-B analysis. Also, he likes to take control and finds delegation difficult with being very competitive as well. He is a loner who likes to rebel against the controls imposed on him whereas Mia has high expressed and wanted control which makes her like structures and procedures while recognizing authorities of others. Craver further has a higher internal locus of control and perceives the high activity as a precursor to success (Mindtools, 2013b). A simple example can be his argument with his boss in which he believes that he single-handedly increased company’s sales and only same approach can produce results. He is highly achievement-oriented along with being arrogant and a strong want to control everything. Mia has a moderate locus of control which makes her a believer in personal skills and influence of external environment. She believed that corrective measures needed to be taken in Chinese franchise should include standardization as well localization and in order to convince her Chinese manager, she traveled to China herself instead of maintaining a virtual communication. When analyzed about tolerance of ambiguity, Carver shows complexity out of other dimensions (Tyran, n.d). He undertook several projects that required fast and quality results and presented better product like than his competitors. Mia, on the other hand, shows novelty on the scale of tolerance of ambiguity. She lacked international exposure however while meeting her manager in China, she had a certain comfort level with the situation in hand. After comparing Carver and Mia’s personalities  on the scale of MBTI testing, it is evident that Carver is a Mastermind (INTJ) who is introverted, logical and highly attentive towards details whereas Mia is a Supervisor (ESTJ) which makes her a strong believer in rules along with having preference for tried methods (Myers et al., 1998).  

Who Wins and Who loses From Public Debt Research Paper

Who Wins and Who loses From Public Debt - Research Paper Example e of the case of United States where public debt amounted to $15.5 trillion much of which has been used to â€Å"finance wars and wasteful conspicuous consumption† (Al-Jazeera, 2011). The stimulus package of President Obama which was meant to pump prime the US economy, which in principle been good, did not worked and only contributed further to the US mounting debt. As a result, Standard and Poor downgraded the credit rating of the United States from AAA credit rating, to AA+ (Bloomberg, 2011). This manifested U.S. government’s inability to cut spending and put its fiscal management in order. In addition, the intramurals of US government officials on how to deal with its public debt also contributed to the downgrading of its credit rating. In this regard, it is the general American public who lost as a result of its public debt which was shabbily managed by its politicians. The amount of debt that the US economy incurred is staggering. In 2012, it is expected to reached $12.7 trillion (usgovernmentspending.com, 2012) without any end in sight. Ideally, the growth or surplus of an economy should exceed the amount of interest of the public debt for the given economy to repay its debt. US is already way passed this point â€Å"where it could service its debt without going deeper into debt, let alone repay it† (Al Jazeera, 2011). According to the Congressional Budget Office (CBO), spending in 2001 to 2009 increased by 6.5 percent of GDP while revenue decreased by 4.7 percent of GDP resulting in a substantial deficit that has to be filled with further spending through debt that resulting to the current astronomical deb. In 2011, GDP was expected to rise by $100 billion with a revenue of $2.16 trillion but spending amounted to $3.45 trillion that resulted to $1.5 trillion that is again to be borrowed compounding the insurmountable debt that the US alre ady have Given the rate of spending compared to realized revenue, it is very clear that the general public

Review Article - Rheumatoid Arthritis & Il-6 Essay Example for Free

Review Article Rheumatoid Arthritis Il-6 Essay Introduction Rheumatoid arthritis (RA) is an inflammatory autoimmune condition principally causing synovial joint inflammation and cartilage erosion. The pathogenesis encompasses intricate cellular and humoural manifestations, and vascular reactions that result in the infiltration of the synovium by white blood cells, of which release inflammatory mediators, inclusive of Interleukin-6 (IL-6). IL-6 serum levels of RA patients as shown by Capell et al. (1993) displayed a median of 55 IU/ml, as compared to that of healthy controls of 10 IU/ml. With a wide-ranging pleiotropy endorsed by both a membrane-bound (IL-6R) and soluble (sIL-6R) receptor, and by the relative omnipresence of the trans-membrane protein gp130, IL-6 endorses a pro-inflammatory effect via its influence on numerous cell types and signalling-pathways. As a result, heightened levels of IL-6 aids in the promotion of osteitis, sequential joint damage, pain/discomfort and impaired function in RA patients. Pleiotropy of IL-6 Interleukin 6 exerts effects on numerous pathways contributing to the pathophysiology of RA. IL-6 as it is called today has been known by several names that exemplify its pleiotropy for example, hepatocyte-stimulating factor known to cause the induction of C-reactive protein (CRP); due to IL-6 association with synovial fibril aggregation has been known as Amyloid protein; a thrombopoietin; both B-cell differentiation and stimulating factor 2; plasmacytoma growth factor; and cytotoxic T-cell differentiation factor. It also causes the differentiation of Th17 cells; is a causative factor in adhesion molecule expression on the surface of endothelial cells, and is involved in the differentiation to mature from precursor osteoclasts cells (REF!!). IL-6 Recptor binding IL-6 implements its influence via a protein complex primarily comprised of a membrane bound IL-6R and a glycoprotein comprised of two intra-cytoplasmic transducer sub-units, gp130. When IL-6 binds to membrane bound IL-6R (mIL-6R) it causes homo-dimerisation of the gp130 sub-units, of which triggers intra-cytoplasmic signal transduction. Whilst expression of gp130 is relatively omnipresent upon the surface of the body’s cells (Akil, et al., 2008), IL-6R is most prominently located on hepatocytes, macrophages, monocytes, neutrophils and select lymphocytes. However, (sIL-6R) of which is systemic also binds IL-6, and just as mIL-6R, can also engage with gp130 for sIL-6-gp130 trans-signalling (REF!). Synoviocytes, for example do not express mIL-6R but do express gp130. Raised levels of IL-6 in the synovium is a characteristic biomarker of RA (Attar, et al., 2010), and Kim, et al. (1996) states enhanced IL-6/sIL-6R in synovial fluid increased the risk of joint destruction, as IL-6 stimulates endothelial cells to express adhesion cytokines and other molecules of which attract inflammatory cells to synovial membrane (Romano, et al., 1997) thus could contribute to exemplifying the significance of sIL-6R in RA pathophysiology. sIL-6R is formed by either an incomplete proteolytic enzymic dissection of mIL-6R or alternative splicing of mRNA (REF!!). With the aforementioned ubiquitous nature of gp130, mIL-6R and systemic sIL-6R, increasing evidence REFERENCES SEE NOTES!! shows that a non-membrane bound, systemic, soluble gp130 (sgp130) found in higher circulatory concentrations than that of sIL-6, also binds IL-6/sIL-6R, thus functioning as a redundency factor inhibiting the cytoplasmic signal-transducing potential of mgp130 REFERENCES SEE NOTES!!, (IL-6/IL-6 receptor system and its role†¦) thus serving as a natural inhibitor of IL-6 signalling (IL-6/IL-6 receptor system and its role†¦). Intracellular signalling gp130 dimerisation brings Janus Kinases (JAKS), a receptor-associated protein complex, into close proximity causing a trans-activation of the two molecule types. Auto-phosphorylation of JAKS occurs, of which causes intracellular signal transduction by recruiting signal-transducers and activators of transcriptions (STAT) that form either hetro or homo dimers and migrate to cell nucleus effecting target gene transcription of various physiological processes (REF). IL-6 can be detrimental to human physiology (REF!), thus expression of proteins known as the suppressors of cytokine signalling (SOCS) function as a negative-feedback system, and are activated by STAT’s. The regulation of the JAK-STAT signalling pathway by SOCS is more specifically down-regulated by SOCS 3 (REF!). SOCS 3 binds JAK’s causing negative-regulation thus functioning as an auto-regulatory mechanism, by inhibiting JAK activity. IL-6 and the Adaptive Immune System The trans-signalling of IL-6 is known to cause the induction of pre-B-cell-colony-stimulating factor (PBEF) in fibroblast cells of the synovium (Bryant, et al., 2006), and since PBEF upon its discovery was considered a B-cell differentiation cytokine(McNiece et al., 1994), it could be considered plausible that IL-6-induced PBEF and the IL-6 maturation of B-cells, collectively contribute to RA. It has been found the effect of IL-6 on plasmablasts indirectly induces the production of B-cell antibodies by assisting elements of CD4+ T-cells (of which act upon activated B-cells) due to elevated IL-21 production (Bond, et al., 2009), thus IL-6 may potentially be a co-adjuvant to humoural immunity enhancement (Bond, et al., 2009). Enhanced levels of the RA associated Rheumatoid Factor are located in the IgA, IgG and IgM isotypes (Ahmed, et al., 2010), and citruline antibodies located in serum and joints, can be linked to the plasmablast-induced antibody production of IL-6 (Ahmed, et al., 20 10). IL-6 enhances T-cell proliferation where they have been mitogen stimulated (Mihara, et al., 2002). IL-6 also impacts T-cell development (Mihara, et al., 2002). Along with transforming growth factor (TGF)- ÃŽ ², IL-6 contributes to Th 17 differentiation, an effector T cell with pro-inflammatory elements, and is further compounded by Th 17 production of the pro-inflammatory cytokine IL-17 (Bettelli, et al., 2007). Interestingly, without IL-6, TGF- ÃŽ ² induces Treg production, of which are Th 17 cell suppressors (Hirota, et al., 2008). CD4+ Th cells have been considered Th 1 and Th 2 based upon their cytokine-producing characteristics (Diehl and Rincon, 2002). Th 1 and Th 2 produce IFN-á µ § and IL-13 respectively, of which are both pro-inflammatory molecules, however whereas IL-6 bolsters IL-4 induced differentiation of Th 2, it causes the inhibition of IL-12 induced differentiation of Th 1 (Diehl and Rincon, 2002). Acosta-Rodriguez, et al. (2007) found that in vitro levels of IL-1ÃŽ ² – induced Th 17 polarisation of naà ¯ve human CD4+ T-cells were heightened by IL-6 involvement. More research however, is required to make clear the full extent of IL-6 role in human Th 17 cell development, in vivo. During inflammation, neutrophils of which are essential inflammatory mediators, systemically increase substantially, resulting in relative neutrophilia. Endothelial cells, macrophages and monocytes all emit IL-6. Neutrophils are directly affected by IL-6 due to the expression of IL-6R. Filer, et al. (2005) found that co-cultured endothelial cells and fibroblasts extracted from synovial fluid of RA patients caused an increase in IL-6 and neutrophil recruitment. Adhesion molecules, of which it has been shown in the work of Woodfin et al. (2010) to be required in the transmigration of neutrophils, are augmented by IL-6 such as vascular cell adhesion molecule – 1 (VCAM) and intracellular adhesion molecule – 1 (ICAM) of which produce chemokine production. Thus neutrophils being the most numerous and systemic of leucocytes have a strong initial synovial presence and is bolstered by the amplification of the inflammatory cascade, contributing to the inflammatory escalation during acute-phase response; and findings from animal and human studies revealed that the blockade of IL-6 caused a reduction in neutrophil levels at inflamed sites (Hashizume, et al., 2008), as well as a reduction in systemic neutrophil counts in RA patients (Deguchi, et al., 2003 and Broll, et al., 2006),thus indicating a prominent role for IL-6 in neutrophilia. IL-6: Acute to Chronic Farnarier, et al. (2003) suggests the transition from acute to chronic inflammation as emphasised by a shift of biomarker from neutrophil to monocyte, is influenced by IL-6. It was found that if stimulated for a number of hours by inflammatory cytokines, neutrophils switched from the production of IL-8 and transitioned to monocyte chemoattractant protein-1 (MCP-1) (Yamashiro, et al., 1999). sIL-6R is released from neutrophils of which in turn causes the chemokine release of endothelial cells, thus Romano, et al. (1997) suggests the IL-6 – sIL6R complex contributes to the release of MCP-1 from endothelial cells. As earlier discussed, neutrophil-count was found to be directly associated with the blockade of IL-6R?!; and endothelial cells expressing the gp130 but not the IL-6R, thus reliant upon the IL-6 – sIL6RÃŽ ± complex for induction of MCP-1 release, i.e. the release of monocyte, not neutrophil specific chemo-attractants (Gres, et al., 2001), it would appear IL-6 tran-signalling plays an integral role in the transition from acute to chronic inflammation via neutrophil and endothelial cells. *CHART SHOWING CELLS THAT RELEASE IL-6!!* IL-6 induces a disintigrin and metalloproteinase with thrombospondin motifs (ADAMTS) and matrix metalloproteinase (MMP) proteinases of which are pivotal in the degradation of extracellular matrix. IL-6 more specifically, has been shown to induce ADAMTS-4 and MMP’s 1, 2 and 13 production in cells lining the synovium and chondrocytes (Hashizume and Mihara, 2009; Hashizume, et al., 2010; 2012). However, it has been suggested the IL-6 – sIL-6R complex has bearing on the extracellular matrix turnover, as it causes generation of tissue inhibitors of MMP’s (TIMP’s) in synovium fibroblasts and chondrocytes (Dayer, et al., 1998 and Hashizume, et al., 2012). The drug tocilizumab (TCZ), an IL-6 inhibitor reduces MMP-3 blood serum levels of RA patients (Garnero, et al., 2010), and has been show to restore biomarkers associated with cartilage turnover (Dayer, et al., 1998). Thus, in RA patients the reduction of IL-6 activity appears to be a mediatory factor in sustainment of healthy joint cartilage. Angiogenesis is a key process in the local inflammatory process. Neovascularisation of the synovium and other angiogenic processes such as hyperplasia of synovial cells and permeation by inflammatory cells are characteristic processes in pannus development and RA pathology (Ballara et al., 2001). In addition to notable constituents of the inflammatory process such as monocytes and T cells, both of which as stated previously have affiliations with IL-6 expression (CITATION OF A FEW), levels of a key angiogenic specific growth factor Vascular Endothelial Growth Factor (VEGF) has also been associated with systemic levels of IL-6, as demonstrated in the work of Hasizume, et al., 2009 and Hagihara, et al., 2003 revealing IL-6 induces VEGF production from synovial cells. VEGF induces proteins that contribute to the breakdown of endothelial basement membrane, including MMP’s, of which increases the permeability of blood vessels, thus allowing enhanced infiltration of inflammatory constituents (Delisle, et al., 2010). VEGF levels accordingly, have been shown to coincide with the articular severity of RA (Hagihana, et al., 2003), and has shown a reduction in response to TCZ (Hagihana, et al., 2003), of which correlates with findings of a semi-quantitative assessment by Akoi, et al. (2011) using ultrasonography that found TCZ responsible for a marked reduction in RA neovascularisation. Bone Remodelling Bone remodelling is a highly regulated process in which mature bone tissue is removed by osteoclasts and formation by osteoblasts. The pathogenesis of RA favours bone loss (resorption) via the excessive production of osteoclasts. Anecdotal evidence by Kazuto et al. (1996) revealed synovial fluid highly +ve for IL-6 –sIL6R complex from RA patients, stimulated increased formation of osteoclasts in mouse co-culture of osteoblast and bone marrow cells. This study coincides with research by Balena, et al. (1994) of which indicated that mice deficient in IL-6 displayed no significant changes in gross or trabecular bone structure. In human studies, biopsies of RA patients revealed that peri-articular bone loss was found to correlate with local excessive presence of IL-6 (Sugiyama, 2001), and work by Garnero et al. (2009) showed the administration of TCZ to RA patients in a multi-centre double-blind placebo-controlled study yielded an increase in bone-formation markers, with a decrease in bone-resorption markers. Collectively, research suggests IL-6 has a negative effect on bone mass. Acute-phase response Acute-phase response is an innate immune reaction in which IL-6 is notably involved via the stimulation of hepatocytes, and is a key inducer of the acute-phase protein CRP. CRP is considered a dependable biomarker of inflammation and RA activity as serum half-life remains constant due to its inflammatory-induced, hepatic-stimulated production being the exclusive systemic determinant and due to its noted increase in RA serum levels (Hirshfield and Pepys, 2003). Anaemia Approximately 1-in-4 RA patients will suffer symptoms of anaemia within the first year (Figenschau, Nikolaisen and Nossent, 2008). The hormone hepcidin, produced in the liver and integral in stemming the metabolism of iron, has been shown in vitro to increase in presence due to IL-6 stimulation of hepatoma cells (Ganz, 2003). This study correlates with Gabayan et al. (2004) in which IL-6 induced patients experienced a 7.5 fold increase in hepcidin production. Anaemia in RA patients, as a result of a hepcidin-IL-6 axis, has limited but supported credence. Osteoporosis has also shown a correlation with IL-6. As mentioned earlier, healthy bone metabolism requires adequate regulation of osteoclasts and osteoblasts, in which excessive IL-6 expression and the Th17 derived IL-17 (Gillespie, et al., 1999) both contribute to excessive osteoclast formation (Campbell et al., 2005). This has also been found to be the case in transgenic mice (De et al., 2006; and Choy and Dayer, 2009) in which bone formation was reduced, and negative ossification was reported. As shown, there are comparable cross-over aspects of IL-6 pathology between RA and osteoporosis. Treatment As highlighted throughout this review, IL-6 plays a pleiotropic pathophysiological role in RA, thus would make an ideal therapeutic target. The most promising and note-worthy of treatments at present, TCZ interrupts IL-6 induced trans-signalling. Numerous studies have shown promising results including a phase III clinical trial in 2005 using the ACR (American College of Rheumatology)* RA activity measure, which had improvement measures of 89, 70 and 47% at ACR’s of 20, 50 and 70 respectively at 52 weeks, in patients treated with TCZ. This multicentre, double-blind placebo-controlled trial by Hashimoto et al. (2004) showed bone resorption and joint destruction could potentially be completely prevented (Kishimoto, 2010), as exemplified when a culture of patient synovial and peripheral mononuclear cells, extracted from the same patients showed that osteoclast generation was completely prevented (Hashimoto et al., 2004; Kishimoto, 2010). At 6 weeks within this study, it was also found that IgG, CRP and serum amyloid A levels all normalised. It has also been suggested that TCZ aids in Th17 differentiation, hence IL-17 production, thus aids in the improvement of RA symptoms (Kimura and Kishimoto, 2010). Other notable studies such as the SAMURAI (Study of Active controlled Monotherapy Used for RA, an IL-6 Inhibitor) and LITHE (TociLIzumab safety and THE prevention of structural joint damage trial) served to enhance conscensus. This humanised, monoclonal antibody has now been approved in many countries^^. 286 With a wide-ranging pleitropy, IL-6 has the most profuse SF and systemic cytokine presence in RA pathophysiology, and coincides with cartilage erosion and disease activity. It has a role in elements of B-cell differentiation and increasing evidence suggests a definite yet ambiguous role in Th17 differentiation. IL-6 has several key positions in immune and inflammatory processes (recruitment, permeation and adhesion of inflammatory elements), and bone and joint degradation, of which over-expression causes adversity, such as release of hepcidin and CRP from the liver contributing to anaemia and inflammation, osteoporosis and pannus development. It plays a key role in the cross-over from acute-to-chronic disease. TCZ has shown much promise in RA therapy by inhibiting IL-6 expression. *ACR 20, 50 and 70 = improvements of 20%, 50% and 70% in disease activity, respectively. ^Disease Modifying Anti Rheumatic Drugs. ^^Japan , April 2008, Europe, January 2009 and USA, January 2010. PUT IN ABSTRACT: The IL-6R, sIL-6R and gp130 system is known as IL-6 trans-signalling References: Capell, H. A., Crilly, A., Madhok, R., Watson, J., 1993. Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity. 52 (3): 232 Annals of the Rheumatic Diseases. [ONLINE] Available at:http://ard.bmj.com/content/52/3/232.full.pdf+htm. [Accessed 23 December 2012]. Angelo, L. S., Hong, D. S., Kurzrock, R., 2007. Interleukin†6 and its receptor in cancer. Cancer Wiley Online Library. [ONLINE] Available at:http://onlinelibrary.wiley.com/doi/10.1002/cncr.22999/pdf. [Accessed 01 January 2013]. Bussolino, F., Ciliberto, G.,Faggioni, R., Fruscella, P., Hinsbergh, V. 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Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study, Journal of Rheumatology, [online] Available at: http://onlinelibrary.wiley.com/doi/10.1002/eji.201040391/full. [Accessed 01 January 2013]. Balint, G., Broll, J., Emery, P. Kishimoto, T., Pavelka, K., Peterson, J., Maini, R. N., Raemen, F., Smolen, Szechinski, J., K., Taylor, J., Thompson, D., 2006. Double†blind randomized controlled clinical trial of the interleukin†6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate, Arthritis Rheumatism Wiley Online Library, [ONLINE] Available at: http://onlinelibrary.wiley.com/doi/10.1002/art.22033/pdf. [Accessed 01 January 2013]. Farnarier, C., Kaplanski, G., Mantovani, A., Marin, V., Montero-Julien, F., 2003. 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Data Security Policy Analysis

Data Security Policy Analysis Dylan Mc Grath   The reason for having a policy: The reason for having the policy is so that the workers at ACME LEARNING Ltd know what to do when they are assessing the personal data of the customers and how they will use the data. A Brief explanation of the companys obligations under the law: There is one main legislation which the company has to obligate by it is called the Data Protection Act 1998 which was also amended in 2003. It was created for when personal details are given to a company they have to keep the details and they cannot be given to anyone outside of the company. Every person who has given their details to the company can request a copy of their information that the company has. The company must send the person their details within 40 days. They can also have their name removed from any marketing list. They could also make a complaint to the data commissioner if the company is not adhering to the Protection Acts rules. A person can claim compensation if they suffer when the company uses their data in a wrong way. Who is effected by how the company uses and stores data? The people that are effected by this are: Teachers and Staff who work for ACME LEARNING Ltd Management Students The Data that is stored about them is: Credit Card/ Bank Details Birth Dates Contact details Name Address Email Gender PPS Numbers Suppliers information Why the data is used by ACME LEARNING Ltd: For advertising and marketing purposes. To have a database of a persons information. For payroll and pension administration To make the names and addresses of people are correct. To stop fraud and money laundering For record keeping What Specific Threats does AMCEs data have? Malware: Malware is software that can harm a computer and can slow down performance. Hacking: Getting into a computer authorized or unauthorized without wanting to cause any damage. Weather Conditons and Fires: data can lost by storms, earthquakes and floods.   Fires can also be started by accident when the server room is too hot. When these weather conditions and fires happen the server rooms can be completely destroyed. Adware: Software that can monitor the users online activities so that the person can be targeted by advertisements. Disgruntled employees Spyware Accidents Theft Human Error Copying data onto storage devices. Trojans Roles and Responsibilities: Data Controller ACME LEARNING Ltd must appoint a Data Controller who is there to deal with the data which is about their customers on a computer and also in a filing cabinet. The Data Controller must: 1: Obtain and process the information fairly. 2: Keep it only for what is it was needed for. 3: Use it for and it should only be given out for a specified purpose. 4: It must be kept safe and secured. 5: The information must be kept up to date and correct. 6: Make sure the data is adequate, relevant and not excessive. 7: It must not be kept for any longer than it is needed for. 8: Give a copy of his/her personal data on their request. Every Employee that works for ACME LEARNING LTD has to be given training on how to use and handle the data. Rules for:1. Data storage: Data on hard drives cannot be deleted. The data has to be stored on the network drive where the I.T department can back it up when they need to. Data that is on paper has to be kept in a safe place. Data has to be protected by strong passwords. All data has to be stored on the server and data has to in a safe location. The Data Controller and only the people who need to access the data are allowed to look at it. Servers and computers that have data have to be protected by a firewall and security software. Data on CDs or DVDs has to be locked away. The servers have to have different sites in case one site goes offline. Data should not be saved on laptops or other mobile devices. There will be two different databases for both staff and students information. The data cannot be stored locally have it in a place where it can be backed up every night. Data has to be backed up every night. The usb ports on all the machines have to be disabled. Every computer in the building has to be rebooted every night at a certain time. There are two databases one for staff and the other for students information. Users have to logout of their computer to make the data stays safe. The person that looks at the data should be able to see the quantity of the data and the duplication. 2. Data use When looking at data on a computer all employees must have their computer locked when they are away from their desk. Employees cannot make a duplicate of any data on a file. When data is being transferred electronically it has to be encrypted. 3. Data accuracy: ACME Learning LTD must keep the data up to date and accurate. Data that is inaccurate should be updated to the correct data by someone that is allowed to edit the data. There are staff that are allowed to edit the data and other staff who are only allowed to read the data. 4. Data access requests: The Data Protection Act lets a person find out if ACME LEARNING Ltd has any information that relates to them. The person has to either fill out a form or write a letter to the company asking for their information. The person has to include identification so that the company knows that they are giving the data to the right person. The person is entitled to: A copy of the data. A description of the use for which it is held. A description of those to whom the data may be shown to. The source of the data. The person may have to pay a fee to access their information which cannot exceed â‚ ¬6.35. The person has to be contacted within 40 days with their data or be told that the company does not have any data about them. 5. Data Disposal: ACME LEARENING LTD will keep the data it has for employees for seven years only if it is financial. ACME LEARENING will keep the students data for three years. If a student has ticked a box to say that they want ACME LEARENING LTD to keep their exam results then ACME LEARENING LTD has to keep the students exam results for a certain number of years. If data is on paper it has to be thrown into a waste bin. It must also be recycled. The paper can also be shredded so that the data on the paper will be destroyed. An incinerator can be used to burn the paper to destroy it so no one can recover any of the data on the sheets. Hard Drive Disposal: At the time the hard drives need replacing an employee must carry out the procedures that need to be done. The procedures are to overwrite a hard drive, get the hard drive destroyed by paying a company that deals with destroying hard drives the right way so that the data is safe from being seen by a person that wants to use it for gaining money. The hard drive can also be degaussed. This removes all the data from the hard drive. Degaussing destroys the magnetic fields on the hard drive. It completely makes the hard drive in tiny pieces so that it cannot ever be used again. Overwriting the data using a program puts binary numbers onto the hard drive. It should be done at least three times to be successful. Tape Media Disposal: The data on the tapes can be overwritten. They can also be incinerated this method will completely destroy the tape. This method will pollute the air.   The data on the tapes can be degaussed. The company can get someone to come in and do it to witness that the tape has been degaussed properly.

Essay On Hacking :: essays research papers

Essay On Hacking A topic that i know very well is computers and computer hacking. Computers seem very complicated and very hard to learn, but, if given time a computer can be very useful and very fun. Have you ever heard all of that weird computer terminology? for and example, Javascript. Javascript is basically a computer language used when programming internet web pages. Have you ever been on the internet and seen words go across the screen or moving images? This is all done by the Java language. If you don not see moving images then its because your web browser cannot read javascript. If you don't know what a web browser is then I will tell you, a web browser is simply a tool used to view the various websites on the internet. All web browsers are different, some only interpret html language, which is another programming language used to design web page and then there are some browsers that can play videos and sounds. Have you ever wondered why when you want to go to a website you have to type http://name of site.com? well I have been wondering for ages but still can't figure out, but sometimes you type ftp:// before the name of the site. This simply means File transfer protocol. You use this when download image files or any other files. Now, onto hacking. Most people stereotype people simply as "HACKERS," but what they don't know is that there are three different types of computer whizzes. First, there are hackers. Hackers simply make viruses and fool around on the internet and try to bug people. They make viruses so simple. The get a program called a virus creation kit. This program simply makes the virus of beholders choice. It can make viruses that simply put a constant beep in you computer speakers or it can be disastrous and ruin your computers hard-drive. Hackers also go onto chat rooms and cause trouble. Chat rooms are simply a service given by internet providers to allow people all over the world to talk. As I was saying, Hackers go into these rooms and basically try to take over because in chat rooms there is one person in control. This person has the ability to put you in control or simply ban you. These hackers use programs that allow them to take full control over any room and potentially, make the computers on the other side overload with commands which in end, makes their computer collapse. Another type of computer whiz is called a cracker, crackers are sort of malicious.

Fitzgeralds The Great Gatsby Essay -- Fitzgerald Great Gatsby 20s Es

Fitzgerald's The Great Gatsby In my presentation, I will be discussing how the 20s played a major role and affected the story, characters, and ultimately, the outcome of the novel, The Great Gatsby. The first topic I will be discussing are the women of the Great Gatsby. The 20s were a time of change in the views of women. They became more open and outgoing in many things. These included not only womens rights, but also their sexuality. This was the age of the "flapper". A flapper was a women who was very outgoing at parties. She smoked, drank, danced, and couldn't hold only one man. Think "Chicago" for a very good example. Renee Zellweger and Catherine Zeta-Jones both played flappers. -Now, technically Daisy wouldn't be classified as a so called "flapper", but she was highly influenced by them. When Gatsby returns, Daisy is still in love with him and, even though she is married, runs away with him, but only for a short period of time. Before the roaring 20s, this would be unthought of, but as the womens rights movements set in, it is not so uncommon of a sight. -Myrtle was also sort of a flapper, though as I said with Daisy, not the best representation in the book. She was also married, and was very poor, yet she was having a long running affair with Tom, Daisy's husband. She was fat, loud, and tried to be as rich as she could, yet everyone saw right though that. Myrtle's ideals played a very important part in The Great Gatsby. -The best representation of...

Ethical Norms of Medical Research Essay -- Pharmaceutical Industry, Br

Branding, according to Parry, is to create a new thinking of the product to customers in the unique way so that the product can compete to others. And, in the pharmaceutical industry, branding is not only creating the new thinking of product, but also defining the best treatment for particular condition. If done so, the condition branding has numerous benefits because it creates consensus internally and externally. Internal consensus which is the activities focus on the problem and solution between brand managers and clinic so that the product can be maximized investment. Beside that, external consensus creates the better relationship between the owner and the clinical community to approach therapeutics (1). However, Fishman argued that branding leads to good sales and profits because the clinical trial researchers are position themselves as mediator between producers, pharmaceutical companies, and consumer, that are clinicians and patients, and they act like experts in that field. Therefore, the researchers create faithfulness to consumer, and in turn branding increase sales (12). As a mediator, researchers involve in the benefit of branding. Somehow, there is a conflict in their role between their benefit and the ethical norm of medical research. Fishman may be right when she implied that the ethical norm of medical research is driven by marketable drugs and marketable diagnoses. Let take a look in the process of how the drugs develop and bring to the market. First of all, the drug which is developed should meet the condition that can treat for disease with certain amount of patients, and then academic medical researchers are person who collect the clinical data, will mediate with FDA to get approval guideline for new drugs; ... ...cluded that With the increasing public†private arrangements being brokered between industry and academia, these ethical issues only become more entangled. Conventional medical ethics is unequipped to deal with these questions. Business ethics is likewise unable to accommodate the particular responsibilities of the biomedical project. The chasm left in between is where the academic researcher now treads, guided only by professional conventions and a growing entrepreneurialism and commercialism in medicine.(24). It may be strict if we say that the drugs market now needs to be control seriously and let the scientist be independent with their research because when drugs consider as other commodity, then patient become as customer not a patient. The patients need to be treated with medical ethical norm so that they can feel they are in treatment with good condition.

Emotionism religion Essay

I call my invented religion Emotionism. My religion will be based mainly on the belief that emotions are a manifestation of one’s faith. It will have the historical drama that is found in Roman Catholicism in that it will deliver faith by rooting this in accounts of people in the past who have been in contact with the founder of the faith. These accounts will be the foundation of my religion because they will fortify the faith by validating the love and compassion that one Jesus Christ had for His people. However, it will have none of the ritualistic practices of Catholicism because all these make it difficult to worship using the heart; instead, they focus on worship with the mind and the body. In the manner of adoration and worship, my religion will follow the ways of Buddhism and will focus on meditation and contemplation. Emotionism will seek to establish the beauty of worship using states of the mind and the heart. It will encourage journeys into one’s consciousness and discoveries into one’s self; and so, like Buddhism, will value man’s intelligence and encourage it to flourish. Emotionism, like Buddhism, will base its practices on the philosophies of transcendentalism so that each Emotionist will seek to rise beyond one’s current level. Emotionists will encourage links between the heart and the elements, between the mind and nature, and the spirit and the universe. My invented religion will promote harmony instead of division, which, although addressed by Catholicism through ecumenism, still exists among the many Christian sects. Emotionism will recognize the universality of things like Hinduism does. It will also adapt the religious passion of Hindus who believe that emotions are a potent force in altering one’s state of being. One other aspect of Hinduism that Emotionism will take into its folds is seeing beyond the physical self and recognizing the connection one human has with another in terms of the spirit – that each spirit comes from a single source and that all spirits are linked together by one common thread. Emotionism will also promote religious zeal the way Muslims do. The religious fervor and faithfulness of Muslims transcend barriers of time and space. Muslims live their faith and this is the kind of quality that I would like Emotionism to have. Emotionists will seek to defend themselves the way they defend their faith and vice versa, something Muslims are known for. Emotionism will therefore have the historical foundations of Catholicism, the adoration methods and philosophical precepts of Buddhism, the passion and recognition for emotions of Hinduism and the religious fervor of Islam. These elements of the various religions that I would like to combine would make for an almost perfect religion so that all the undesirable elements of each religion are discarded and only the desirable aspects adapted. While it is perhaps impossible that such a religion could exist, it is an exercise in intellect to know that religion can in fact be a conglomeration of beliefs and elements emanating from various other, more ancient practices and cultures. I envision my religion to be all encompassing so that no rules and laws determine who can join my religion. The most important aspect of my religion is the fact that it will attempt to unite all those divided by the eccentricities of religion, especially Christians and Muslims. It will seek to propagate understanding and the reality that even with different religions, all the peoples of the world actually just subscribe to a singular concept, and that is the concept of love and compassion.

Green Tea and Weight Loss in Overweight and Obese Adults

Obesity has become a growing health issue which is associated with increased risk of chronic diseases such as coronary heart disease, hypertension, type 2 diabetes, osteoarthritis, stroke, sleep apnea, and certain cancers (Auvichayapat et al. , 2008; Maki et al. , 2009; Nagao et al. , 2005). In the United States there are an estimated 72 million overweight or obese adults (as cited in Maki et al. , 2009).Currently, the most effective treatment for obesity is a combination of reducing energy intake and increasing energy expenditure, yet the most popular treatment is pharmacotherapy (Auvichayapat et al. , 2008, Diepvens, Kovacs, Nijs, Vogels, & Westerterp-Plantenga, 2005). Recently, researchers have found antiobesity effects in green tea (Maki et al. , 2009). The objective of this term paper is to depict the claim of green tea and its effectiveness on weight loss in overweight and obese adults. Review of the Literature Overweight and Obese and Weight LossThe basic reasoning of overweig ht and obese individuals is an imbalance between energy consumption and energy expenditure (Diepvens et al. , 2005). To achieve weight loss, a negative energy balance must occur and can be achieved by decreased energy consumption or increased energy expenditure (Auvichayapat et al. , 2008; Diepvens et al. , 2005). Genetics may also be linked to obesity in several ways. Genetics may be associated with susceptibility to fat storing and the controllability of food intake (as cited in Shepherd, 2009).It has been inferred that green tea may reduce body weight and increase satiety which will positively effect body composition (Auvichayapat et al. , 2008; Diepvens et al. , 2005; Maki et al, 2008; Nagao et al. , 2005). Components of Green Tea Green tea contains two major active ingredients which may be contributed to combating obesity: catechin and caffeine (Auvichayapat et al. , 2008; Diepvens et al. , 2005). Research has suggested that green tea catechins block the enzyme catechol O-methy ltransferase, thereby stimulating the sympathetic nervous system (Auvichayapat et al. 2008; Belza et al. , 2009). The stimulation of the sympathetic nervous system may be responsible for increased thermogenesis, fat oxidation and satiety (Auvichayapat et al. , 2008; Belza et al. , 2009). Green tea catechins may also contribute to increased antioxidant, antiviral, antiplaque-forming, anticancer activities, and decreased blood pressure and total cholesterol (as cited in Nagao et al. , 2005). Research has suggested that caffeine may promote thermogenesis and fat oxidation that positively affect body composition (Auvichayapat et al. , 2008; Belza et al. 2009; Diepvens et al. , 2005). Caffeine obstructs the degeneration of intracellular cyclic adenosine monophosphate, leading to increased norepinephrine release (Auvichayapat et al. , 2008). The increased norepinephrine may lead to thermogenesis and may enhance satiety (Auvichayapat et al. , 2008). Effects of Catechin and Caffeine Supplem entation on Overweight and Obese Adults Maki et al. (2009) conducted a study to investigate whether green tea catechin intake increased exercise-induced abdominal adiposity loss in overweight and obese adults in the United States.The researchers supported previous claims of green tea catechins’ positive effect on general weight loss, but further investigation was needed to conclude that green tea catechin consumption has a positive effect on body composition and abdominal adiposity. The study was a randomized, double-blind, controlled clinical trial that took place in two clinical research sites – Bloomington, Indiana and St. Petersburg, Florida. The male and female participants were of good general health and sedentary.The participants were between the ages of 21 and 65, had a waist circumference of 87 centimeters or greater (women) or 90 centimeters or greater (men), and a total cholesterol of 5. 2 mmol/L or greater. Participates agreed to consume no more than two ca ffeinated drinks a day and avoid medication or supplements that contained caffeine or catechin. The eligible participants were randomly assigned a beverage of catechins (625 mg) or a control beverage (0 mg) per day. Both the catechin and control beverage contained the same amount of carbohydrates, sodium, as well as caffeine (39 mg).Since this was a double-blind trial the eligible participants and staff were unaware of the assigned beverages. The eligible participants were asked to maintain caloric consumption, and required to increase their activity level by attending three, one-hour supervised exercise sessions a week for a total of 12 weeks. The Maki et al. (2009) study yielded 107 participates that completed the entire trial and met the set requirements. The average age of the participants was 48 years, about one-half were males (catechin, 49. 2%; control, 55. %), and most participants were of non-Hispanic white ethnicity (91%). Maki et al. (2009) found that the catechin group e xperienced (P = 0. 079) a greater loss of body weight than the control group at week 12. This supports results of other trials (Auvichayapat et al. , 2008; Belza et al. , 2009; Nagao et al. , 2005). The results of the Maki et al. (2009) study showed no difference in percentage changes in fat mass (P = 0. 208) or intra-abdominal fat area (P = 0. 125). However, total abdominal adipose area (P = 0. 013) and abdominal subcutaneous adipose area (P = 0. 19) decreased at week 12 (Maki et al. , 2009). Maki et al. (2009) concluded that catechins (625 mg/day) may have positive effects on exercised-induced loss of abdominal adiposity. Auvichayapat et al. (2008) conducted a randomized, controlled, experimental study to investigate green tea and its effectiveness on weight loss in obese Thais. The study included 60 Thai participates who were between the ages of 40 and 60 and had a body mass index of 25 kg/m2 or greater. Forty-two participates were females and 18 were males.The participants were required to have good health history with no current or prior metabolic or systemic diseases and not currently taking prescribed medication. The participants were randomized into two groups, a green tea group and a placebo group. The participants in the green tea group consumed a 250 mg green tea (100 mg catechin) tablet after breakfast, lunch, and dinner. The participants in the placebo group also received a tablet after breakfast, lunch, and dinner containing cellulose which was identical in appearance to the green tea tablets.The participants’ heights were determined by the use of a wall-mounted ruler and body weight was determined by the use of a digital scale. Body mass index was calculated by body weight (kg) divided by height (m) squared. Body fat percentage was measured by the use of a calibrated skinfold calipers. The sum of the triceps, subscapular, and iliac skinfolds were compared based on sex and age from the Jackson study to determine body fat percentage (as cit ed in Auvichayapat et al. , 2008). Resting energy expenditure was measured by the use of the Douglas bag system by indirect calorimetry (as cited in Auvichayapat et al. 2008). The air expired by the participants were analyzed by a computerized data acquisition system from which resting energy expenditure were calculated with the use of Weir’s formula (Auvichayapat et al. , 2008). Body mass index, body fat percentage, and resting energy expenditure were measured at baseline, and during the fourth, eighth and twelfth weeks of the study. In comparison, the green tea treatment group exhibited a significant difference (P < 0. 05) in weight loss during the eighthand twelfth weeks of the study as compared to the placebo treatment group.Auvichayapat et al. (2008) concluded that green tea can increase energy expenditure and therefore increase weight loss in obese Thais. Nagao et al. (2005) conducted a random, double-blind, controlled, experimental 12-week study to examine the effec ts of catechins on body fat loss. The researchers included 25 healthy Japanese men between the ages of 24 and 46 who ranged from normal to overweight according to body mass index (as cited in Nagao et al. , 2005). The 25 participants were randomly placed into two groups, a catechins group (n = 17) and a placebo group (n = 18).The requirements for the individuals were to consume 90% of the calculated energy intake requirement, to withhold from consuming large amounts of catechins, polyphenols, or caffeine, and to maintain their current level of exercise. Anthropometric measurements and computed tomography were administered by trained physicians at baseline and every four weeks thereafter for the 12-week study. Waist circumference was measured at the umbilical level while the participants were standing in accordance with the Japan Society for the Study of Obesity (Nagao et al. , 2005).The participants’ body fat ercentages were measured by the use of a bioimpedance analyzer and skinfold caliper method. Body fat percentage and lean body mass were derived from the ratio of total body weight to body fat. The skinfold caliper method utilized measurements at the lower end of the scapula and the intermediate region on the lateral side of the arm, and the sum of the two values were recorded. The measurement of fat was calculated by computed tomography. Computed tomography imaging was performed for visceral fat measurement by utilizing FAT SCAN software developed on the method developed by Tokunaga et al. as cited in Nagao et al. , 2005). The use of the FAT SCAN software, subcutaneous fat area and visceral fat area were obtained from abdominal computed tomography image. Subcutaneous fat area and visceral fat area were summed together to obtain the total fat area. The results of the Nagao et al. (2005) study showed that the reduction in waist circumference (P < 0. 01), skinfold measurements (P < 0. 05), and total fat area (P < 0. 05) was significantly grea ter in the catechin group (690 mg) than that of the placebo group.In conclusion, catechins (690 mg/day for 12 weeks) decrease total body fat and may be useful in preventing and combating obesity. Belza et al. (2009) conducted a randomized, double-blind, controlled study consisting of 12 healthy and normal weight male participants (age: 23. 7,  ±2. 6 years). Each participant was instructed to maintain their daily dietary and physical activity habits throughout the study. The treatments being analyzed were in the form of tablets containing 500 mg green tea extract (125 mg catechins), 400 mg tyrosine, 50 mg caffeine, or placebo.Each treatment was separated by a minimum of three days. The main focus of Belza et al. (2009) was to examine the compounds tyrosine, green tea extract, and caffeine, and their individual effects on thermogenesis, appetite sensations, and ad libitum energy intake. A ventilated hood that was tested weekly to ensure reliability was used to assess resting metabol ic rates of each participant. Participants were instructed to fast the evening prior to, as well as refrain from medication, alcohol, and strenuous physical activity 24 hours before respiratory assessments.A baseline respiratory measurement was acquired for each participant during the first 25 minutes of each assessment. The assessment then continued with 30-minute intervals in which respiratory measurements were recorded for a total of four hours. Each respiratory assessment for each individual was executed on the same time of day and on an identical schedule. The participants’ appetite sensations were analyzed using the Visual Analogue Scales which included subjective questions about sensations of hunger, satiety, prospective consumption, and fullness (Belza et al. 2009). Each participant completed the Visual Analogue Scales prior to the respiratory assessment to obtain a baseline measurement, and subsequently throughout the respiratory assessment. Another test each partici pant completed was the ad libitum meal. The participants were instructed to consume the ad libitum meal at a constant pace and to terminate consumption when satiety was reached.The amount of ad libitum meal consumed was used as the assessment of ad libitum energy intake. Belza et al. 2009) found that caffeine produced a thermogenic response of 6% above the baseline assessment as compared to the placebo (P < 0. 0001). No significant difference was found for thermogenic response with the tyrosine and green tea extract treatments as compared to the placebo (Belza et al. , 2009). Belza et al. (2009) stated that too small of a sample size was tested to conclude any appetite suppressant value of the treatments administered, and additional investigation with a large sample size is needed. Diepvens et al. 2005) administered a study to investigate the effects of green tea and a low-calorie diet on resting energy expenditure and body weight in overweight females. The researchers hypothesiz ed that green tea would increase resting energy expenditure and decrease body weight. The study was an experimental, double-blind, parallel-design, placebo-controlled trial including 46 overweight females between the ages of 19 and 57 and a body mass index between 25 and 31 kg/m2. All participates were of good health and moderate caffeine-users (200-400 mg of caffeine a day).Two groups were randomly assigned to each treatment: a green tea treatment (n = 23) and a placebo treatment (n = 23). All 46 participants consumed a low-calorie diet consisting of 60% of estimated energy expenditure and consumed three tablets daily (9:00 a. m. , 1:00 p. m. , 6:00 p. m. ) of either placebo or green tea (75 mg caffeine, 375 mg catechins). Diepvens et al. (2005) utilized an open-circuit, ventilated-hood system to assess energy expenditure, as well as fat and carbohydrate oxidation.Anthropometric measurements were assessed using a digital balance (body weight) and a wall-mounted stadiometer (height) . BMI was calculated by dividing body weight in kilograms by height (m) squared. Diepvens et al. (2005) concluded that there was not a significant difference between the green tea and placebo groups in reducing body weight. Diepvens et al. (2005) contributes the low thermogenic effectiveness of green tea to the low-caloric diet because of the reduction of sympathetic activity caused by the low-caloric diet.The reduced sympathetic activity reduces noradrenalin release which is partially responsible for thermogenesis (as cited in Diepvens et al. , 2005; Auvichayapat et al. , 2008). Summary In summary, the effects of green tea on weight loss may be attributed specifically to the catechins and caffeine, the active components of green tea. The researchers found that a positive correlation occurred between the consumption of green tea and energy expenditure, fat oxidation, total fat area loss and satiety which will contribute to the prevention and reduction of obesity.Although several stu dies found that there was not a significant difference in energy expenditure, fat oxidation, total fat area loss and satiety between the green tea and control groups, there was nevertheless a difference. Perhaps with the long term consumption of green tea, the benefit will be exponentially larger. It is beneficial to note that while the consumption of green tea is not a solution by itself, it can be used as part of the process for weight loss and optimizing health for currently overweight or obese adults.References Auvichayapat, P. Prapochanung, M. , Tunkamnerdthai, O. , Sripanidkulchai, B. , Auvichayapat, N. , Thinkhamrop, B. , †¦ Hongprapas, P. (2008). Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiology & Behavior, 93(3), 486-491. doi:10. 1016/j. physbeh. 2007. 10. 009. Belza, A. , Toubro, S. , & Astrup, A. (2009). The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. European Journal of Clinic al Nutrition, 63(1), 57-64. doi:10. 1038/sj. ejcn. 1602901. Diepvens, K. , Kovacs, E. M. R. , Nijs, I. M. T. Vogels, N. , & Westerterp-Plantenga, M. S. (2005). Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females. British Journal of Nutrition, 94(6), 1026-1034. doi:10. 1079/BJN20051580 Maki, K. C. , Reeves, M. S. , Farmer, M. , Yasunaga, K. , Matsuo, N. , Katsuragi, Y. , †¦ Cartwright, Y. (2009). Green Tea Catechin Consumption Enhances Exercise-Induced Abdominal Fat Loss in Overweight and Obese Adults. Journal of Nutrition, 139(2), 264-270. doi:10. 3945/jn. 108. 098293. Nagao, T. , Komine, Y. , Soga, S. Meguro, S. , Hase, T. , Tanaka, Y. , & Tokimitsu, I. (2005). Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J of Clin Nutr, 81(1), 122-129. Retrieved from http://www. ajcn. org. libaccess. sjlibrary. org/cgi/reprint/81/1/122. pdf Shepherd, A. (2009). O besity: prevalence, causes and clinical consequences. Nursing Standard, 23(52), 51-57. Retrieved from http://web. ebscohost. com. libaccess. sjlibrary. org/ehost/ pdfviewer/pdfviewer? vid=4&hid=8&sid=44d81a55-f6d5-40b7-808f-239f2569d782%40sessionmgr10

Purpose of a Job Description Essay

The primary purpose of a job description is to identify the duties, essential functions and requirements of the position. Job descriptions also serve several other important functions. A good job description can assess work flow and eliminate duplication of effort and also help to assist in the evaluation of the employees’ job performance. It should be a statement of what duties and responsibilities the employee is expected to complete and a means for achieving them. Job descriptions can also be used as recruitment tools, compensation surveys and other benchmarks tools. Job descriptions are used for different purposes by the employee and the Human Resources Department. Human Resource managers, can use job descriptions for employee training and development and establishing and updating performance standards. In general, a job description includes the title, a description of the tasks performed, and information on working conditions. It can also include any other attributes that the employer requires for that position such as: education, knowledge, skills and personality suitability. (Verma, 2007) Many business challenges such as the introduction of new technology, or increased business competition, can be more easily met when employees are well prepared and trained to have the required skills. The company I work for, for example, informs all the employees with the latest updates within the company by sending a letter. With detailed job descriptions, you can compare the actual tasks of employees to what needs to be done within the organization. This helps you easily identify critical areas that need to be addressed, ensuring you have a global view of your organization’s strengths and weaknesses and, at the same time, a detailed view of each employee’s areas of strengths and areas for improvement or change. In the recruitment process, a job description gives potential employees comprehensive information about the job for which they are applying. An accurate and effective job description filters applicants who are being evaluated for the opening – helping generate a higher-quality pool of applicants. It also serves as a resource to the supervisor who is filling a position by helping determine the types of selection tools that should be used when hiring. The Sim-Industries HR department has been in place for 1, 5 years now and they still have not made time to develop job descriptions, because the management did not see this as a priority. The company was in its initial fase and all the employees were expected to be flexible during that period. For example, the finance manager worked in the finance department but was also involved in the human resource department and he was furthermore acting as the PA of the CEO. Currently we have two hundred employees and I believe that it is time to start setting up job descriptions. We need structure and the different kind of functions within the company should be defined. It must be clear what duties a colleague has and what he or she is responsible for within the organization. It will be a lot clearer for new employees to have a job description as they will then have a better understanding what the organization is expecting from them. As I can see now in the organization, many employees do not exactly know what their duties are and who is responsible for what. Therefore I think that we should consider the introduction of another type of management. With for example performance management, we will reach more personal involvement between employees and managers due the fact that the system is based on managing the strategy of the organization. The goals in the organization will be more specific when the managers constantly ask themselves: ‘How are we going to reach that? ’ and ‘Who is responsible for that? ’ When they start using the new system, the strategy will become clearer.

History of Real Madrid Cf

Martin Torrijos 12th Grade English November 21, 2012 Real Madrid FC Real Madrid Football Club is one of the oldest, most successful clubs in the world. Ever since its inception in 1902, the club has won countless titles, and has been a perennial contender for its entire existence. Many of the sport’s biggest, most notorious legends have worn the pure white uniforms that have become synonymous with the team. With a history of excellence, and a winning tradition that continues to this day, Real Madrid’s already unbelievable legacy looks to become even greater with the passage of time.This incredible club was founded on March 6th 1902 as â€Å"Sociedad de Madrid FC, and its first ever president was Mr. Juan Padros. In one of the first team meetings, the board agreed to the dress team white shirts, with matching shirts and socks, as a tribute to one of his favorite football clubs (Corinthia of London). This decision inadvertently led to the creation of one of football†™s most iconic looks, the pure white Real Madrid home kits. In the very same year that the club was founded, it won its first championship, the â€Å"Campeonato Regional Central† (Central Regional Championship).Two years later, On May 21, 1904; Madrid FC participated in the founding of FIFA (the international federation that, to this day, is still the central governing body of the sport), with the federations of Belgium, Denmark, France, Netherlands, Spain, Sweden and Switzerland (and their respective top clubs) all present. Decades later, on June 29, 1920; the club received a letter from the King Alfonso XIII of Spain granting them the title of a â€Å"royal†, a distinction that very few Spanish clubs can boast.Not even some of the country’s most successful clubs (Barcelona, Valencia, Malaga, and Atletico de Madrid; for example) share the distinction of being â€Å"royal† clubs. Since then, the club has utilized its present name, Real Madrid Club de Fu tbol. In the same decade that they were declared football royalty, they participated in the inaugural league championship of Spain in 1929, where it finished in second place behind their soon-to-be lifelong rivals F. C. Barcelona. The following season the club began a tradition of spending made many signings, including goalkeeper Ricardo Zamora, for whom they paid 150,000 pesetas to Espanyol.Despite the large investment, Real Madrid had a discrete participation and came nowhere near winning the title. In 1931, with the establishment of the Second Spanish Republic, Real Madrid was stripped of the title of â€Å"Royal† and renamed to Madrid Football Club again. The club, however, further invested on players and obtained League 1931/32, the first in Madrid, undefeated. The success was repeated in the 1932/33 season, with Brazilian Olivares consecrated as the first big-name scorer of the team.The first era of Real Madrid-style success soon ensued, and the club won three consecuti ve leagues (1933-34, 1934-35 and 1935-36), and were also cup winners in 1934 and 1936 after beating Valencia C. F. and F. C. Barcelona respectively. With the outbreak of the Spanish Civil War sports activities were suspended from 1936 to 1939. After the end of the political turmoil in Spain, the club regained its title of â€Å"Royal†. The war, however, left Real Madrid without several of their stars, so they decided to hire many players, including Sabino Barinaga, a world class midfielder who arrived from Southampton FC in England.On September 15, 1943 ex-player and former coach Santiago Bernabeu was unanimously named club president, ushering in a prosperous stage of the club’s history. This move allowed Real Madrid get the â€Å"bicampeonato†, winning both the league and domestic cup, in 1946 and1947. The club, however, suffered such poor results during the 1948-49 campaign that league winning coach Quincoces Jacinto, with just one year in office, resigned fro m his post midway through the season.In January 1948 Michael English relieved Quincoces, and managed to save the team from descending into the â€Å"Segunda Division†, the second tier league of Spanish football, which sends its top three teams into the first division while receiving the bottom three from the â€Å"Primera Division†. Although English had stars like the great Pahino at his disposal, the â€Å"Merengues† spent the next few years in mediocrity and finishing mid-table. On March 6, 1952, to commemorate the 50th anniversary of its founding, the team hosted an international friendly tournament , where they lost the final ost to Club Deportivo Los Millonarios from Colombia. Despite the loss, the club spotted Argentine player Alfredo di Stefano and hired him from Millonarios in 1953, along and Spaniard Francisco Gento from Racing de Santander. This signing proved to be excellent, as Di Stefano would lead Madrid to an era of absolute success, and is still regarded as one of the top five players to ever play for Madrid. With â€Å"Pahino† Molowny, Di Stefano and Gento, the â€Å"Merengues† got the 1953-54 league title, after a 21 year dry spell. Di Stefano was crowned top scorer of the tournament, a feat that he would repeat four more times in Madrid.Under the direction of Spanish coach Jose Villalonga, and with a team of players like Juan Alonso, â€Å"Marquitos† Rafael Lesmes, Miguel Munoz, Jose Maria Zarraga, â€Å"Joseito† Alfredo di Stefano, Hector Rial and Francisco Gento, Real Madrid conquered 1954-55 and 1956-57 league. They also participated in the first two editions of the European Cup, which they won by beating Stade de Rennes in the French league in the Parc des Princes and ACF Fiorentina of Serie A D’Italia in the Santiago Bernabeu, respectively, in the 1955-56 and 1956-57 editions.Argentina’s Luis Carniglia relieved Villalonga, and, with the additions of Raymond Kopa, Jose Santam aria and Ferenc Puskas; the team won the 1957-58 European Cup, and beat AC Milan and Rennes in the finals of the â€Å"Coup d’Europe† in 1958 and 1959, respectively. Following years of Di Stefano-led success, the club began a new era in 1966. Madrid gave relief to the old idols of Madrid with a team of young Spanish people like Joseph Araquistain, â€Å"Pachin† Pedro de Felipe, Manuel Sanchis , â€Å"Pirri†, Ignacio Zoco Francisco Serena, Amancio Amaro, Ramon Grosso and Manuel Velazquez; and led by the veteran Francisco Gento.The rejuvenated tea won the European Cup, after years of futile performance. In the 1970? s, the now-veteran players won Real Madrid five Leagues and three Domestic Cups. The happy period of the club’s history would soon end. On June 2, 1978 Santiago Bernabeu died during the World Championships in Argentina. Soon after, in September, Luis Carlos became president of Madrid. During the reign of Luis Carlos (1978-1985), the team won 2 Leagues, 2 Cups and one UEFA Cup. In those years he was formed what came to be known as the â€Å"Quinta del Buitre† (The Vulture’s Five): Emilio Butragueno ( nicknamed the Vulture†), Michel, Manuel Sanchis, Rafael Martin Vazquez and Miguel Pardeza were all instrumental to the team’s success. In 1981, Real Madrid was defeated in the final of the Champions League for the first time, against Liverpool FC. La Quinta del Buitre was one of the best generations of home-grown Real Madrid players, starting with their win the Second Division title in 1984 with Real Madrid Castilla, the subsidiary of the Club. That generation won five consecutive league (1986-1990) , a Domestic Cup in 1989 and a second title of the UEFA Cup in 1986.In 1985, Luis Carlos retired from the presidency due to his advanced age and was succeeded by Ramon Mendoza (1985-1995). This new generation was led by Mexican striker Hugo Sanchez, bought from Atletico Madrid. They, like the Quinta del Buitre before them, achieved great success (although not as much as their predecessors). The era of victorious accomplishments was broken in 1991, when F. C. Barcelona (led by legend Johan Cruyff) managed to win four consecutive league titles and one European Cup in 1992. During those years, the Madrid only won a Copa del Rey (Domestic Cup) in 1993.At the end of that dark period, the last remnants of the Quinta del Buitre were dissolved with the departures of Butragueno and Michel Vasquez. However, another big player in history came from the Madrid youth academy, Raul Gonzalez Blanco. Commonly known by his first name only, Rauis believed by many to be the best Madrid homegrown player ever. In 1995, he returned Madrid to its winning ways, winning the league with the help of coach Jorge Valdano and signings new signings Michel Laudrup, Amavisca and Jose Redondo.The joy would prove to be short-lived, as the team failed to win any major titles in the 1995/1996 season, Valdano was f ired because of poor performances and the huge debt accumulated for Real Madrid. Real Madrid finished the season outside the European places, so it did not play in any European competition next season. After a radical restructuring of club, Madrid won the Liga 1996/1997 being directed by Fabio Capello, but he left the club due to their discussions and conflicts with then-president Lorenzo Sanz and was succeeded by Jupp Heynckes.The Madrid team led by Heynckes won the seventh European Cup (which has been renamed Champions League ) in 1998, winning the final against Juventus in Turin by a solitary goal he scored on 66 minutes of the meeting by Predrag Mijatovic, breaking 32 years of drought without winning it, but he was fired due to poor performance league. After a season without a title, Vicente del Bosque came to coach in November 1999, making a debut to promising young goalkeeper Iker Casillas. Del Bosque managed to conquer the Eighth European Cup in 2000 after defeating Valencia CF 3-0 in the final.Shortly after, Florentino Perez was elected president of Real Madrid, with a promise to end the club’s debt. On July 16, 2000 held new presidential elections. Sanz lost his re-election to Florentino Perez, who from this moment became the fourteenth president of Real Madrid. Immediately after, Perez bought Brazilian Flavio Conceicao fro Deportivo La Coruna, Frenchman Claude Makelele from Celta Vigo and Albert Celades of F. C. Barcelona. But no purchase had more impact than that of Portuguese winger Luis Figo, who was bought for 60 million from arch-rivals F.C. Barcelona. This moves started the â€Å"Galacticos† Era. This era was marked by great econoinc spending, and the purchase of many of the world’s biggest stars. Players like Ronaldo, Roberto Carlos, Zinedine Zidane, David Beckham, and Figo all ushered Madrid to great heights. In 2001, Madrid won the league again, and Raul was named top scorer. The team won two league titles (2000/2001 and 2002/2003) and the ninth European Cup in 2002 against Bayer Leverkusen thanks to a goal from Zidane right at the end of the first half.After that, the team spent 3 consecutive seasons without a title, one of the worst losing streaks in its history, prompting the resignation of Florentino on February 27, 2006. With Ramon Calderon as the new president, the club won two League titles: (2006/2007 and 2007/2008) and the Spanish SuperCup (2008) with two different coaches (Capello and Schuster), despite failures in the Champions League. In the 2008/2009 season, there was a scandal which forced the resignation of Calderon in January 2009, and he was succeeded by Vicente Boluda.He organized the transition to return to the presidency of Florentino Perez as the only candidate in the 2009 elections. With the return of Florentino Perez for the 2009/2010 season, the club bought Cristiano Ronaldo, had long sought by Calderon, and Kaka, breaking records for the most expensive players in history (C ristiano Ronaldo 96 million euros, Kaka 67. 2 million euros). Also, the club made other expensive such as Karim Benzema (35 million) and Xabi Alonso (34 million euros). As he signed to coach Manuel Pellegrini, Villarreal from the C.F. , thus beginning the Second Age of Galacticos . However, it was not enough and Real Madrid failed to win a title in 2010, despite having added 96 points in the league, a record surpassed only by the 99 champion. The good league season contraste with the early eliminations in the Doestic Cup and Champions League the sixth consecutive time falling eliminated in second round of the continental showpiece. Pellegrini ended up being removed and replaced by Jose Mourinho, who dismissed two emblematic players Raul and Guti.After 18 years of drought, Mourinho managed to win the Copa del Rey. This was the first title in the second stage of Florentino Perez as the first title from Jose Mourinho at Real Madrid. The following year, Mourinho led Madrid to a league t itle, while breaking the record for most points (100), and most goals scored in a single season (121). Today, Mourinho is currently sitting at third in La Liga, and Madrid has just qualified for the next stage of both the Copa del Rey and the Champions League. The future of this club appears to be just as bright as its illustrious history.